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An epigenome-wide association study involving 32 TRD patients undergoing ECT found longitudinal methylation changes at different CpG sites and gene regions (e.g., in FAM20C, IQCE, RUNX3 loci) that were associated with clinical improvement, though these results did not survive correction for multiple comparisons

Meanwhile, the concentrations of 12-HETE and 15-HETE increased, which can be further metabolized into endogenous anti-inflammatories ( FIGURE 4 Decrease of the Intracellular ROS Level by GPX4 Activator We also tested whether GPX4 activator would be effective at reducing cytosolic ROS

Muijsers RB, Goa KL

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