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Sabate M, Ibanez L, Perez E, Vidal X, Buti M, Xiiol X, Mas A, Guarner C, Forne M, Sola R, Castellote J, Rigau J, Laporte JR: Paracetamol in therapeutic dosages and acute liver injury: causality assessment in a propective case series

In consequence, lipid peroxidation products regulate multiple signaling cascades implicated in apoptosis and inflammation, such as the NF-B pathway, in which reactive aldehydes activate NF-B by promoting IB degradation and phosphorylation-mediated inactivation of anti-apoptotic Bcl-2, thereby enhancing pro-inflammatory signaling [45]

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