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Previously in colon biopsies from patients affected by ulcerative colitis and Crohns disease, bromelain in vitro experiments resulted in diminished amounts of IL-2, IL-6, IL-4, G-CSF, Gm-CSF, IFN-, CCL4/macrophage inhibitory protein (MIP)-1, and TNF, implying a role in inflamed colon against pro-inflammatory cytokines and chemokines (131)

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