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Challenges include safety concerns (e.g., impaired wound healing from long-term MMP inhibition) and functional redundancy, where MMP-2 or MMP-12 might compensate for MMP-9 inhibition, necessitating multi-target inhibitors or combination therapies (Sang, 1998

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Response of chick parathyroid glands to the vitamin D metabolites, 1,25-dihydroxycholecalciferol and 24,25-dihydroxycholecalciferol

The cells are constantly exposed to mechanical stress as they pass through the vascular system