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This adaptive response may be caused by mutations that deactivate or activate tumor suppressor genes or oncogenes under hypoxic conditions

The peptides selected for cancer vaccine development can be classified in two main type: tumor-associated antigens (TAAs) and tumor-specific antigens (TSAs), which are captured, internalized, processed and presented by antigen-presenting cells (APCs) to cell-mediated immunity

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Hansen R, Sb M, Skjelbred CF, Nex BA et al (2005) GPX pro198Leu and OGG1 ser326Cys polymorphisms and risk of development of colorectal adenomas and colorectal cancer