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found that circ_0001273, as a cancer-promoting factor that upregulates SLC1A5 expression by binding to miR-622, which increases Gln uptake by tumor cells, consequently enhancing tumor growth and inhibiting cell apoptosis (57)

In addition, thyroid nodules that are found to be suspicious for malignancy must be removed along with the remainder of the thyroid gland to prevent the spread of thyroid cancer

Mechanistically, loss of the PUFA -oxidation enzyme 2,4-dienoyl-CoA reductase 1 increases cellular PUFA burden, elevates phospholipid hydroperoxides, and triggers ferroptotic death in cancer models 345

This is achieved by multiplication of (or 1/ ) with the fraction of transporters that can carry out net transport