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Rhodiola rosea is known to elevate monoamine concentrations and modulate pathways involved in the stress response, whereas Ginkgo biloba is recognized for its ability to enhance cerebral perfusion, safeguard against oxidative damage, and facilitate synaptic plasticity

378 In DA neurons, reduced expression of PGC-1 has been observed, suggesting that PGC-1 dysfunction may play a role in the clinical pathogenesis of PD

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