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(2012), pyocyanin displayed cytotoxicity against RT4 human urothelial cells in a concentration-dependent manner from 25 to 50 M leading to accelerated cell senescence which was also confirmed by a significant increase in the expression of senescence-associated--galactosidase

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However, preclinical in vivo studies showed that it might be possible to overcome at least the second obstacle, with the development of stable in vivo and inducible long-term expression of target short hairpin RNA using dimerizing drugs such as doxycycline or tetracycline ( Conclusion The IGF system has been involved in the oncogenesis of the majority of solid tumors

2014;6:a021857