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C.Al-RawhaniM.AccarinoC.BuscheC.GrantJ.et al (2018)

Safety and side effects A proper daily dosage of a vitamin B12 supplement is very safe

Homocysteine is an inflammatory marker that may increase risk of thrombosis and endothelial dysfunction, cause errors in vascular smooth muscle proliferation [4] and skeletal muscle metabolism [3] , and contribute to heart disease

Results Deficiency of NQO1 increases antiviral response in vivo Mycobacterium tuberculosis increases expression of NQO1, and knockdown of NQO1 activates NF-B and triggers production of proinflammatory cytokines [21]