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In recent years the emergence and spread of artemisinin resistance in South-East Asia, sub-Saharan Africa, India, South America and Papua New Guinea has contributed to treatment failures 1

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Phospholipase A2, reactive oxygen species, lipid peroxidation in cerebral ischemia

There is evidence that these cytokines do not cross the healthy blood-brain barrier and they are rapidly broken down after release but passage between the CNS and blood still remains a possibility (Steensberg et al., 2006