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Consistent with the hypothesis that other angiogenic factors maintain VEGF-independent vessels, pharmacologic intervention with a broad spectrum anti-angiogenic antagonist (suramin), a vascular disrupting agent (combretastatin), or a combination of VEGF and Notch pathway inhibitors reduced the established networks

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, Considering the significant reduction in TLS on day 30 post-IRI, we investigated oxidized lipids within the kidneys on day 21 post-IRI, a timepoint corresponding to active formation of TLS