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State of the art care is to add a friendly yeast called Saccharomyces boulardii (by prescription: Florastor)

Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline

7.6 Integrative perspective and future outlook Taken together, both antioxidant-based and EV-based interventions face shared translational limitations rooted in model relevance, standardization, and clinical validation

Importantly, although A is generally localized toward the synapses, evidence from AD and Downs syndrome (DS) with early AD symptoms exhibit intraneuronal A 142 accumulation that precedes Tau pathology and extracellular A plaque formation (Takahashi et al., 2017