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doi: 10.2147/ott.S220533 64 JoAGreenAMedinaJEIyerSOhmanAWMcCarthyETet al

126 Trombetta-LimaM.Sabogal-GuquetaA

These receptors are coupled to inhibitory G-proteins (G i/o ), which inhibit adenylyl cyclase, deplete cyclic AMP (cAMP) levels, and suppress neuronal firing by opening potassium channels