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A reduction in the microbial variety in the intestine during childhood has been shown to increase the risk of developing asthma (180) and the use of broad-spectrum antibiotics may increase the predisposition to allergic airway diseases thus demonstrating the correlation in the intestine-lung axis

The molecular basis behind Wolbachia -mediated resistance to pathogens is not entirely clear, but it seems to involve enhancing the mosquito's innate immune system [28,200,201,217]