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Under normoxic conditions, HIF-1 is degraded via the ubiquitination pathway mediated by proteins such as prolyl hydroxylase domain (PHD) enzymes and the von HippelLindau (VHL) tumor suppressor protein

We obtained a total of seven major groups of cells, which were dopaminergic neurons, non-dopaminergic neurons, astrocytes, oligodendrocytes, OPCs, endothelial cells/pericytes and microglia/macrophages