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These cascades involve the activation of NF-B and MAPK pathways, upregulation of inflammatory cytokines, and overproduction of reactive oxygen species (ROS), collectively accelerating cellular senescence and tissue degradation 8,9,10,11,12

AB staining identified sperm cells with abnormal chromatin packaging (dark blue nuclei), whereas AO staining distinguished between spermatozoa with normal DNA (green) and damaged DNA (orange/red) 99

Its recognised biochemical name is gamma-L-glutamyl-L-cysteinylglycine

Strikingly, we uncovered the AKT1-PRMT7-GLUD1 axis as a critical controller of tumor growth, providing a potential target and strategy for clinical treatment of gastric cancer