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Anatomical structures characterized by anomalous MRS signals in bipolar disorder are some of the key components of the cortico-limbic regulatory pathways, involved in regulation of mood, cognitive processing, autonomic, and endocrine response

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This release can occur through different mechanisms, such as nanoparticle dissolutionan instability that arises under specific pH conditions, typically at lower pH, leading to matrix dissolutionand polymer swelling, a process in which nanoparticles swell at certain pH conditions, both ultimately resulting in drug release (Karimi et al., 2016)

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