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doi: 10.1172/jci110480 244 FullerBMMohrNMSkrupkyLFowlerSKollefMHCarpenterCR

The increase in pro-inflammatory cytokines over anti-inflammatory cytokines recorded in the present study confirms tissue inflammation, as previously mentioned (70, 77)

Most adult patients suffer recurring, life-threatening bouts of rhabdomyolysis, increasing the disease burden on both patients and health care systems (1, 3)

2.2 LAM's immune response and cell signaling pathways During the process of Mtb infection, LAM can regulate the host's immune response and infection progression through various cellular pathways