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Determinations of the weights of organs from all F 1b adults and five male and five female weanlings from the F 1b and the F 2b litters showed increased organ:body-weight ratios for the liver at 200 and 800 ppm and for the kidney and brain at 800 ppm in adult F 1b females

Therefore, TJs restrict the free transportation of polar solutes such as ions and solutes through paracellular diffusion channels by imparting the high transendothelial electrical resistance (TEER) of the BBB (23)