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The safety and efficacy of GH secretagogues

NAC may be supportive in APD by: Helping replenish glutathione, which plays a role in regulating immune responses Reducing oxidative stress that can worsen mast cell activation and inflammation Supporting overall inflammatory balance, particularly during hormonally driven immune flares Some research also suggests NAC may influence mast cellmediated pathways indirectly 13 , which may be relevant in conditions where histamine release contributes to symptoms

Moreover, the use of inhaled GSH needs to be reappraised, the researchers wrote, and future studies should consider the actual inflammatory status of the airways when treatments of this kind are targeted.

Oppermann M, Freedman NJ, Alexander RW, Lefkowitz RJ