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For observational studies reporting serum vitamin B12 levels, the certainty of evidence was upgraded from low to moderate due to the large and consistent magnitude of effect across studies, despite heterogeneity

Where Phase I or Phase II human trials exist, they are noted in the compound page summary

According to the randomization procedure, Group 1 was assigned to the novel methylcobalamin nasal spray (NASO B12) and Group 2 was assigned to methylcobalamin oral tablet for the treatment of vitamin B12 deficiency during the study period of 15 days [Figure 1]

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