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This occurs through downstream molecules such as eNOS, 39,177,178 mTOR, 179,180 GSK3, 176,181 STAT3, FOXO3, 182 Smad1/5/8, 183 Lipoxygenase, NO, 184 PGI, 184 and ET-1

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TNFAIP3 rs10499194 (OR = 1.33) drives inflammation through dysregulated NF-B inhibition, strongly correlating with ACPA-positive RA ( PADI4 rs2240336 facilitates protein citrullination and subsequent ACPA production (OR = 0.88), exhibiting heightened significance in Asian populations ( IL6R rs2228145 protective variant (OR = 0.93) modulates inflammatory cascades through IL-6 receptor regulation (Okada et al., 2014)

In general, normal esophageal lining is pale pink and smooth, while intestinal metaplasia is salmon-colored and coarse