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Its activity has been associated with reduced permeability disturbances and improved resistance to mucosal injury, particularly in models involving non-steroidal anti-inflammatory drug exposure (10)

Systemic side effects from the tiny amount of benzyl alcohol in each dose are exceedingly rare in adults

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This difference could be explained by a lower amount of adipose tissues in the thigh and upper arm compared with the abdomen and buttocks, which could impact the absorption of buprenorphine (lipophilic drug) during the early release process (i.e., at the time of the peak)