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Liquid chromatography-mass spectrometry (LC-HRMS/MS) For untargeted metabolomics analysis, samples were analyzed using an Impact TM II high-resolution mass spectrometer from Bruker Daltonics (Bruker Daltonics, Bremen, Germany) coupled with an Elute UHPLC system (Bruker)

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It is important to note that the conflicting findings exist in different studies may be due to the variability in factors such as age, gender, lifestyle, and comorbidities among the patient cohorts

A tooth infection is a condition caused by harmful bacteria breaking down the outer enamel and compromising the tooth pulp