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10.1016/j.cbi.2010.11.005 113 LawlorN.KhetanS.UcarD.StitzelM

Given the significant upregulation of PKM2 during renal glycolytic reprogramming [32], we hypothesise that a similar lactate-mediated regulatory mechanism may operate within glomerular endothelial cells, actively promoting diabetic nephropathy progression through sustained activation of pro-fibrotic pathways

An Open-Label, Phase I Study of Dasatinib in Combination with Decitabine in Patients (Pts) with Accelerated or Blastic Phase Chronic Myeloid Leukemia (CML)