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This theory matches data from the German prospective multicenter study ALLIVE including 22 MDS and 90 AML patients and some smaller studies, which show an increase in NTBI and LIP levels during allogeneic HSCT ( During the course of AML, signs of iron overload have also been described

This was achieved by maximizing the activity of reactions that are associated with upregulated genes and minimizing flux through reactions that are downregulated in a condition, while simultaneously satisfying the stoichiometric and thermodynamic constraints embedded in the model using linear optimization 44,81

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Long-term use of metformin (for type 2 diabetes) or proton pump inhibitors can also deplete B12 levels over time