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These therapies aim to enhance WL and improve metabolic outcomes by engaging multiple hormonal pathways, with preclinical and early-phase clinical trials supporting their potential as next-generation obesity treatments [1623]

Moreover, HSP70 prevent its own mRNA from proteotoxic stress in hippocampal and spinal neurons by translocation of the mRNA into neurites (Leone et al., 2024)

A fibroblast activation protein -activatable nanoagent co-delivering diethyldithiocarbamate and copper for tumor therapy and imaging

Impaired activity of methionine synthase results in elevated blood concentrations of homocysteine, while impaired activity of L-methylmalonyl-CoA mutase results in increased concentrations of a metabolite of methylmalonyl-CoA called methylmalonic acid (MMA) in blood and urine