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These mitochondrial protein adducts are thought to cause mitochondrial dysfunction and to promote oxidant stress.17 Indeed, high levels of protein adducts have been detected in the serum of patients with APAP overdose.17 Detection of elevated levels of these APAP-protein adducts by high-pressure liquid chromatography (HPLC) can be used for clinical indication of APAP hepatotoxicity

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PEPstrMOD: structure prediction of peptides containing natural, non-natural and modified residues