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As examples, some of these predictions are stated here: Under conditions of B12 insufficiency, excess folic acid intake will cause the following: Diversion of holoTC from serum to hemopoietic cells to support reticulocyte proliferation Loss of holoTC in urine due to interference of its reuptake by the megalin-receptor complex in the renal tubules Reduced availability of holoTC to the liver, brain, and other tissues due to its diversion to the hemopoietic system and loss in the urine

Each component was selected for its distinct mechanism of action, creating a multi-pathway approach to tissue repair research

[DOI] [PMC free article] [PubMed] [Google Scholar] 117.Yin SJ, Si YX, Chen YF, et al

Topical vitamin C in concentrations between 10-20% is generally safe for continuous use, while the sustainability and safety of prolonged glutathione use for cosmetic purposes requires more research