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Small-molecule inhibitors of cGAS enzymatic activity (e.g., RU.521, G140, PF-06928215) or STING signaling (e.g., H-151, C-176) have shown promise in preclinical neuroinflammation and neurodegeneration models by suppressing excessive type I interferon and cytokine production [12, 196]

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Although bias could not be ruled out (considering the generally weak exposure assessments), given the consistency of null findings, the studies that were reviewed did not provide support for a positive association with cancers of the colon or rectum