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Gueudry J, Wechsler B, Terrada C, Gendron G, Cassoux N, Fardeau C et al

3, 4, 8 Neuropsychiatric changes occur in the hepatic porphyrias (ALA-dehydrase-deficiency porphyria, AIP, porphyria cutanea tarda, hereditary coproporphyria, and variegate porphyria) with excess production of ALA and porphobilinogen (PBG), and there is a somewhat linear relationship between their concentration and the severity and duration of symptoms