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A minimalist and robust chemo-photothermal nanoplatform capable of augmenting autophagy-modulated immune response against breast cancer

The LC treated monolayers of VSMCs in 25-cm 2 culture flasks were rinsed twice with 1 mmol/L EDTA in PBS, lysed with Triton lysis buffer (50 mmol/L TrisHCl, pH 8.0, containing 150 mmol/L NaCl, 1% Triton X-100, 0.02% sodium azide, 10 mmol/L EDTA, 10 mg/mL aprotinin and 1 mg/mL aminoethylbenzenesulfonyl fluoride) and then saved after centrifugation

Approach Phase 2b trial arm Duration 24 weeks Review Point Week 12 and 24 Notes METAOD006 (OPTIONS) used 24 weeks at oral doses 0.25, 0.5, or 1 mg/day in 502 obese adults

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