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As a follow-up to Lehninger's work several years later, Nishikimi and co-workers observed that the gene that codes for gulonolactone oxidase is actually present in humans, but is not active due to the accumulation of several mutations that turned it into a non-functional pseudogene (Nishikimi & Yagi 1991)

Factors such as age and associated medical conditions can also impact individual response to TB-500

Dai XJ, Jia Y, Cao R, Zhou MN (2023) Naringin prevents cognitive dysfunction in aging rats by inhibiting toll-like receptor 4 (TLR4)/NF-B pathway and endoplasmic reticulum stress