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[,] However, NAC (25200 mg/kg) had no effect on compulsive water consumption in male rats with schedule-induced polydipsia

For these uses, you want the compound to stay in the gut which is exactly what oral delivery achieves

Excess media was removed and replaced with 100 L TGhL containing either GSH and GSSG (0.5 mM-2 mM), BME (0.1 mM-2 mM) or mucin (0.25 mg/mL-2.5 mg/mL) and incubated at 20C