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This is further supported by the fact that epigenetic processes, such as DNA methylation and histone modifications, may also be disrupted by MTHFR polymorphisms [83]

doi: 10.1016/j.bbrc.2018.11.067 168

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Younger individuals with already-robust GH output may see less relative improvement, since tesamorelin works by stimulating endogenous GH rather than replacing it