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3.3.3 Involvement of cytokines and signaling pathways Although MenSCs lack HLA-DR expression, limiting their antigen-presenting capacity, they exert immunoregulatory effects through the secretion of various paracrine molecules, including IL-6, TGF-, COX-2, PGE2, indoleamine 2,3-dioxygenase, and programmed death ligand-1 (Malik et al., 2018

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