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Although methotrexate didnt improve heart health, it was associated with several troubling side effects compared to placebo, including: A 23% higher rate of gastrointestinal (GI) symptoms, such as nausea and vomiting A 42% higher rate of lung problems, including cough, trouble breathing and in a small percentage of people, pneumonitis, a potentially fatal lung inflammation A 15% increase in infections A doubled risk of skin cancer, although the overall rate was low Two kinds of side effects can occur in children who take methotrexate for JIA: symptoms, particularly nausea and vomiting, caused by the drug itself and by anticipating taking it

This is especially relevant for those who struggle with gastrointestinal discomfort

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Western blot analysis After transfection with WNT4-siRNA or control siRNA (the sequences was shown in Table S1), PC12 cells were treated with a series of concentrations of FSZ and differentiated for 6 days