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Immediate medical attention is required for such responses

Furthermore, these ameliorative actions were mediated by the specific recruitment of the endogenous noradrenergic system

The induction of an inflammatory milieu and BBB impairment have been uncoupled by inhibition of nitric oxide synthesis in the cuprizone model [29] or by targeted overexpression of claudin-1 in EAE [44] that both support BBB tightness but presumably do not (directly) affect expression of pro-inflammatory molecules

Experiment design and treatment After the adaptation period, the rats were randomly divided into five groups of six animals: i