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Gao M, Zhang N, Liang W

In the genesis of argyria development, several silver sources have been identified, which can be divided into three main categories: iatrogenic, occupational, and alternative medicine-related (Table 1)

Postmortem studies show elevated GSK3 activity in individuals with MDD and bipolar disorder, and animal models demonstrate that GSK3 inhibition in the nucleus accumbens produces antidepressant effects (150, 151)