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No clear effect of treatment on the short-term neutralizing activity was observed as none of the treatments analyzed (tocilizumab, corticosteroids, type-I IFN or protease inhibitors) were associated with higher or lower magnitude of neutralizing responses

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However, none of the therapeutic candidates have been successful so far [10-12] , with the major impediment for most being a failure to cross the blood-brain barrier

While SLC12A2 and CLDN11 protein levels remain unchanged between homozygous KI and wild type Hgf del10/del10 littermates, SLC12A2 demonstrates a slight, significant increase in expression in the Hgf del10Neo line