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Nevertheless, several key observations in our model, including the reduced number of ciliated cells, the increase in secretory cells, and a loss of cellular resilience in IPF-derived phBECs, are consistent with reported epithelial alterations in IPF in vivo, supporting the value of our model as a meaningful platform for mechanistic investigation 71,72

(3) In experiments with both primary and immortalized oligodendrocyte progenitor cells, adding TB-500 at concentrations between 25 and 100 ng/mL appears to cause higher levels of microRNA-146a

They also reported that Myo promotes imaginal disc growth in Drosophila 44

These combined experiments, uncover some distinctive features between the GDF11 and GDF8 mature domains in vivo , suggesting that the endogenous mature ligands are functionally different