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We next tested mutations in the MCM 2-7 helicase that unwinds the DNA template (MCM2 [ cdc19.P1 ], MCM4 [ cdc21-M 6 8 ] or MCM5 [ nda4-108 ]), but failed to detect loss of viability (Fig

The main mechanism responsible for the observed permanent distal sensory loss is associated with the death of sensory neurons (i.e., nerve cell necrosis) due to the binding of oxaliplatin to mitochondrial DNA [36]