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On the contrary, heterozygous mutations resulting in substitution of the key active site arginine cause IDH1 R132 and IDH2 R172 to gain a new function

Guoji E, Sun B, Liu B, et al

The aged lens epithelial cells exhibit a notably vulnerability to ferroptosis 9

Gottlieb E, Vander Heiden MG, Thompson CB: Bcl-x L prevents the initial decrease in mitochondrial membrane potential and subsequent reactive oxygen species production during tumor necrosis factor alpha-induced apoptosis