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TF adheres to transferrin receptor 1 (TfR1) on the cell surface, facilitating the internalization of the TFTfR1 complex into endosomes [37]

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Matrine protects colon mucosal epithelial cells against inflammation and apoptosis via the Janus kinase 2 /signal transducer and activator of transcription 3 pathway

We observed the same in our cohort of 70 patients: compared to patient matched healthy tissue, tumors had significantly higher levels of GSSG which they appeared to redox-balance by enhancing GSH production, reflected by a an accumulation of GSH as well as its precursors (Fig