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353 In PASMCs from MCT-PAH rat models, HMGB1 triggers ERK1/2 signaling, leading to Drp1 phosphorylation and mitochondrial fragmentation, which promotes autophagy activation, resulting in BMPR2 degradation, ID1 downregulation, and PASMC proliferation/migration

These metabolites have a half-life of up to 28 h, and after being released, they reach the blood and lymph nodes of the whole body, and finally enter different organs such as the liver and kidneys for catabolism, which is ultimately discharged through feces or urine for 24 to 28 h (25, 3640) (Figure 4)

in: PubMed | Google Scholar | 1 The First Affiliated Hospital of Jinan University, Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of the Chinese Ministry of Education, Guangdong Province Key Laboratory of Pharmacodynamic Constituents of Traditional Chinese Medicine and New Drugs Research, and The Sixth Affiliated Hospital of Jinan University, Jinan University, Guangzhou, China

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