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Preclinical research evidence Animal Experiments Obese mouse model: After subcutaneous injection of AOD 9604 (250 g/kg) daily for 8 weeks, the body weight of obese mice decreased by 12%, the subcutaneous fat mass decreased by 25%, and the weight of epididymal adipose tissue decreased significantly

Lipolysis proceeds in an orderly and regulated manner, with different enzymes acting at each step

For example, NAMPT expression changes during diseases such as cancer, diabetes, and fatty liver disease 211 , and eNAMPT levels decrease with age 328

For instance, an individual with significant metabolic challenges might show more pronounced shifts than one already operating at peak metabolic efficiency