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F., Hou, Y., Lautrup, S., et al

Behavioral/Non-pharmacologic Treatments Guideline Statement 9 Patients should be educated about normal bladder function, what is known and not known about IC/BPS, the benefits versus risks/burdens of the available treatment alternatives, the fact that no single treatment has been found effective for the majority of patients, and the fact that acceptable symptom control may require trials of multiple therapeutic options (including combination therapy) before it is achieved

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They learned, for example, that massive doses of interleukin-2, which at the time was being tested as a cancer treatment, could greatly boost levels of the specific immune cells that HIV destroys