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Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate-to-severe plaque psoriasis over 52 weeks: a phase III, randomized controlled trial (ESTEEM 2)

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Although the latter of these can be associated with certain adverse complications (Baxter and Colville 2016), this approach has been successful in treating infections caused by Clostridium difficile (Kumar and Fischer 2020)