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Therefore, rigorous validation using human-derived organoids or patient-derived xenograft models is essential to ensure preclinical findings translate effectively to clinical contexts

In addition, knockout of Kir4.1 in rodent models has been reported to cause severe neurological deficits, including sensorineural deafness, ataxia, epileptiform activities, and early postnatal death (Nwaobi et al., 2016)

Policymakers are now proposing to expand this approach across the entire DoD through a Strategic Breakthrough Funding program, with awards potentially reaching $30 million

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