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Lysosomal acid lipase is the main enzyme that hydrolyzes low-density lipoproteins and the modified forms of low-density lipoproteins, playing a pivotal role in lipid decomposition and prevention of excessive lipid accumulation 144

While its roles in nuclear factor erythroid 2-related factor 2 (Nrf2) activation and histone deacetylase (HDAC) inhibition are well-established, this review provides a novel synthesis by integrating disparate research scalesa multiscale perspective that spans from the genetic and epigenetic regulation of glucoraphanin biosynthesis in plants to SFNs recently elucidated effects on ferroptosis, cancer stem cells (CSCs), and the tumor immune microenvironment in humans

In July 2021, Anifrolumab received FDA approval in the USA for treating adult patients with moderate to severe SLE who are on standard therapy

Konstantinidou M, Li J, Zhang B, Wang Z, Shaabani S, Ter Brake F, et al